Neurosurgeon Dr. Tyler Matthews reports his boss, who is involved in a Medicare scam. Soon thereafter he is investigated by the DEA for possessing illegal drugs. His lawyer suggests he accepts a government deal in spite of his insistence that he is being framed. If he refuses he might never practice medicine again. He has already lost his wife Nancy because of the drug charge, so he reluctantly agrees.
Later, Matthews finds work at a medical center in Seattle where a computerized record keeping system is being tested that is expected to dramatically reduce medical errors. When his patient unexpectedly dies, he investigates and concludes that the record system is flawed, causing the death and reports his findings. With millions of dollars at stake if the software is rejected, the bad guys strike back with a vengeance.