Lycosidae
An experiment to breed wolf spiders that will hunt and kill rats produces more spectacular (and scary) results than anticipated. Some of these Super Spiders escape from the lab and create a new species of predator on earth.
The main focus of the book seems to be the transformation of an ordinary group of people into "spider hunters" they develope techniques and skills that allow them to effectively battle these creatures. Kind of like Ghost Busters but ...
