Frank (Joel Murray) is an insurance salesman plodding through life. He's divorced, his daughter wants nothing to do with him and - more than anything else - he is overcome with a sense of disgust towards American pop culture.
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One day, after hearing others in his office make fun of the latest “American Superstarz” contestant (whom Frank believes to be mentally handicapped), he is fired for sending a coworker flowers. Sinking further into depression and with nothing else to live for, Frank sees a reality show starring Chloe - a spoiled rich child - and gets an idea.
The next day, Frank stakes out Chloe's school with a gun. Roxy (Tara Lynne-Barr) pesters him about what he's doing, but eventually leaves him. When Chloe exits the school, Frank approaches and -after a botched attempt to light her car on fire - shoots her point blank and runs away.
He retreats to a hotel, where he plans to commit suicide, but finds Roxy has followed him. She's excited about what he did, and tells him he shouldn't commit suicide before doing more, citing a number of people that “deserve to die.”
So Roxy and Frank trek across the country in a bid to kill several prominent figures such as blowhard talk show hosts and televangelists who preach against homosexuality.
But Frank and Roxy begin to bicker over their intentions, and the hypocrisy of what they're doing slowly creeps into their minds. As the police close in, Frank must make a decision about whether killing is truly the appropriate way to cleanse society, and whether the world might be better off if he was dead, too.