A kind scientist tries to remove his annoying alter ego, only to cause himself to lose brain function as his alter ego runs free. Sherman Klump is a portly and jolly scientist who, in the first film in this series, created an alter ego for himself: Buddy Love, a young and svelte man with endless chatter and even more endless ego. After his alter ego possesses him at his father's retirement dinner and ruins the whole affair, Sherman is humiliated and willing to do whatever it takes to rid his body of Buddy Love once and for all. He is warned that this procedure may take some of his physical or mental health as well, but he is resolved to do it: he successfully removes the Buddy Love gene from his DNA. However, the blob of DNA accidentally touches the hair of a dog and from this combination emerges Buddy Love, now full separate from Sherman Klump and ready to inflict damage upon the world. Luckily for Sherman, Buddy finds himself constantly distracted by cars, cats, and tennis balls, due to having been spliced with dog DNA. Unluckily for Sherman, the warning about the side effects becomes reality, and Sherman starts losing his intelligence at a scarily rapid rate. All the while, we spend time observing Sherman's large and eccentric family: Sherman's father stumbles upon Sherman's newest invention, a youth potion, and goes out painting the town red as a young man again. Sherman's grandmother, however, finds Buddy Love and forces him to go to bed with her. When Sherman finds out they must put Buddy back inside of him in order to save his life, they must track Buddy down before Sherman's last brain cell dies away.
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Best part of story, including ending:
It's an incredibly gross film, with a lot of sex jokes and scatological humor, but it has its moments, and watching Murphy play every member of his family is fun.
Best scene in story:
Grandma Klump's seduction of Buddy Love is incredibly gross but incredibly funny. Murphy makes for a very creepily and hilariously realistic old lady.
Opinion about the main character:
Sherman is nice enough but behaves recklessly in this film. He's more sympathetic and likable in the series' previous installment, but he does fine with what he's given here.